In postmenopausal women with advanced HR+, HER2-negative breast cancer when letrozole or anastrozole fails,

Prescribe AFINITOR plus exemestane to...



Up to 70% of cases of breast cancer have mutations in the PI3K/Akt/mTOR pathway; hyperactivation of this pathway can contribute to endocrine resistance.1-5

Double Median PFS


Median PFS was 7.8 months [95% CI, 6.9-8.5] with AFINITOR® (everolimus) Tablets plus exemestane vs 3.2 months [95% CI, 2.8-4.1] with placebo plus exemestane (HR=0.45 [95% CI, 0.38-0.54]; P<0.0001).6

Excerpts from the experts

Victoria: A Case Study of HR+, HER2-Negative Advanced Breast Cancer Following Progression on NSAI Therapy

Blackwell Video
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Kimberly Blackwell, MD

Professor of Medicine

Duke University

Richard Michaelson, MD

Chief Medical Officer for Oncology

Saint Barnabas Medical Center

Diane: A Case Study of HR+, HER2-Negative Advanced Breast Cancer Following Progression on NSAI Therapy

Mayer-Lipton Video
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Ingrid Mayer, MD

Breast Cancer Specialist

Vanderbilt University Medical Center

Allan Lipton, MD

Professor of Oncology

Milton S. Hershey Medical Center

Ellen: A Case Study of Progression to the Viscera Following NSAI Therapy in HR+, HER2-Negative Advanced Breast Cancer

Peacock Video
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Nancy Peacock, MD

Medical Oncologist

Tennessee Oncology

Denise A. Yardley, MD

Medical Oncologist, Senior


Sarah Cannon Research Institute

Coverage and support* from the very beginning

Our program provides comprehensive support to you and your patients throughout the treatment journey with AFINITOR. Get appropriate patients started on treatment promptly with a 14-day free trial of AFINITOR, the $25 AFINITOR Co-Pay Card or foundational assistance, and coverage support from our reimbursement experts.

*Eligibility requirements exist for all components for the AFINITOR Patient Support Program.

Is it time for a different treatment approach?

In the BOLERO-2 trial, following progression on an NSAI,


of patients in the endocrine monotherapy arm were estimated to have progressed at 3.2 months.6

Abbreviations: BOLERO-2, Breast Cancer Trials of Oral Everolimus-2; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; HR+, hormone receptor-positive; MOA, mechanism of action; mTOR, mammalian target of rapamycin; NSAI, nonsteroidal aromatase inhibitor; PFS, progression-free survival.