PATIENTS TALK ABOUT THEIR AFINITOR THERAPY

PATIENTS TALK ABOUT THEIR AFINITOR THERAPY
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HELPFUL RESOURCE FOR YOUR TREATMENT JOURNEY

AFINITOR PATIENT BROCHURE
 

LEARN MORE IN THE AFINITOR PATIENT BROCHURE

AFINITOR PATIENT BROCHURE
 

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What You Can Do When Diagnosed with PNET

Take an active role in managing your disease

  • Keep your health care team up to date about the prescription and nonprescription drugs that you take
  • Record your symptoms as accurately as possible
  • If you have other health conditions, be sure to monitor them
  • Do not hesitate to speak up and ask questions about your condition and treatment

Keep Your Health Care Team Informed

Keeping an open dialogue with your doctor is very important when you are taking AFINITOR® (everolimus) Tablets or any other medication. By telling your doctor about any progress you are making, how you are feeling, or medications you are taking, you will help your doctor choose the treatment that is best for you.

Download the AFINITOR Patient Brochure including a doctor discussion guide, symptom tracker, and medication tracker.

Important Safety Information

AFINITOR can cause serious side effects that can even lead to death. If patients experience these side effects, they may need to stop taking AFINITOR for a while or use a lower dose. Patients should follow their health care provider’s instructions.

Please see additional Important Safety Information at the bottom of this page.

Please see full Prescribing Information for AFINITOR, including Patient Information.

Engaging your personal advanced PNET support team

Your journey with advanced PNET is not one you are coping with alone. Your family and friends can be there to help you with daily tasks, as well as with talking to your doctor and helping you take your medication. Allowing your caregivers, family, and friends to play an important role in your health and well being can help them be closer to you. You can also turn to support groups in order to connect with other people who have been affected by PNET.

Here are some ways your family and friends may be able to help. They can:

  • Go with you to the doctor, and take notes and ask questions for you
  • Be there to listen when you need to talk
  • Help out with everyday tasks

You are not alone

As you continue along on your advanced PNET treatment journey, keep in mind that having cancer does not change the person you are. Talk to your health care team and learn as much as you can. Do not be afraid to ask for help from your doctors, friends, and support team whenever you feel you need it. Most importantly, always remember that you are not alone.

 

Important Safety Information

AFINITOR® (everolimus) Tablets can cause serious side effects, including lung or breathing problems, infections, and kidney failure, which can lead to death. Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. AFINITOR can cause incisions to heal slowly or not heal well. Mouth ulcers and mouth sores are common side effects, occurring in up to 86% of patients taking AFINITOR. AFINITOR can affect blood cell counts, kidney and liver function, and blood sugar and cholesterol levels. Regular blood tests should be performed before starting AFINITOR and as needed during treatment to check blood cell count, kidney and liver function, and blood sugar and cholesterol levels.

Please see additional

Important Safety Information.

 
 

Important Safety Information

Patients should not take AFINITOR if they are allergic to AFINITOR or to any of its ingredients. Patients should tell their health care provider before taking AFINITOR if they are allergic to sirolimus (Rapamune®) or temsirolimus (Torisel®).

AFINITOR can cause serious side effects that can even lead to death. If patients experience these side effects, they may need to stop taking AFINITOR for a while or use a lower dose. Patients should follow their health care provider's instructions. Serious side effects include:

Lung or Breathing Problems: In some patients, lung or breathing problems may be severe and can even lead to death. Patients should tell their health care provider right away if they have any of these symptoms: new or worsening cough, shortness of breath, chest pain, difficulty breathing, or wheezing.

Infections: AFINITOR may make patients more likely to develop an infection, such as pneumonia, or a bacterial, fungal, or viral infection. Viral infections may include reactivation of hepatitis B in people who have had hepatitis B in the past. In some people these infections may be severe and can even lead to death. Patients may need to be treated as soon as possible. Patients should tell their health care provider right away if they have a temperature of 100.5˚F or above, have chills, or do not feel well. Symptoms of hepatitis B or infection may include the following: fever, chills, skin rash, joint pain and inflammation, tiredness, loss of appetite, nausea, pale stools or dark urine, yellowing of the skin, or pain in the upper right side of the stomach.

Angioedema: Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. Talk with your health care provider before taking AFINITOR if you are not sure if you take an ACE inhibitor medicine. Get medical help right away if you have trouble breathing or develop swelling of your tongue, mouth, or throat during treatment with AFINITOR.

Kidney Failure: Patients taking AFINITOR may develop kidney failure. In some people this may be severe and can even lead to death. Patients should have tests to check their kidney function before and during their treatment with AFINITOR.

Delayed Wound Healing: AFINITOR can cause incisions to heal slowly or not heal well. Call your health care provider right away if your incision is red, warm, or painful; if you have blood, fluid, or pus in your incision; if your incision opens up; or if your incision swells.

Before taking AFINITOR, tell your health care provider about all your medical conditions, including if you:

Tell your health care provider about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Using AFINITOR with certain other medicines can cause serious side effects. Keep a list of medicines you take and show it to your health care provider when you get a new medicine. Especially tell your health care provider if you take St John’s wort (Hypericum perforatum), medicines that weaken your immune system (your body’s ability to fight infections and other problems), or medicines for:

  • Fungal infections
  • Bacterial infections
  • Tuberculosis
  • Seizures
  • HIV-AIDS
  • Heart conditions or high blood pressure
 

If you are taking any medicines for the conditions listed above, your health care provider might need to prescribe a different medicine or your dose of AFINITOR may need to be changed. Tell your health care provider before you start taking any new medicine.

Common Side Effects: Common side effects include mouth ulcers. AFINITOR can cause mouth ulcers and sores. Tell your health care provider if you have pain, discomfort, or open sores in your mouth. Your health care provider may tell you to use a special mouthwash or gel that does not contain alcohol, hydrogen peroxide, iodine, or thyme.

Other common side effects include:

  • Rash, dry skin, and itching
  • Diarrhea
  • Infections
  • Feeling weak or tired
  • Swelling of arms, hands, feet, ankles, face, or other parts of the body
  • Stomach pain
  • Nausea
  • Fever
  • Loss of appetite, weight loss
  • Headache
  • Vomiting
  • Cough, shortness of breath
  • Nose bleed
  • Nail disorders
 

Other side effects that may occur with AFINITOR:

 

Tell your health care provider if you have any side effect that bothers you or does not go away.

These are not all the possible side effects of AFINITOR. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information for AFINITOR, including Patient Information.

The brands listed are the trademarks or register marks of their respective owners and are not trademarks or register marks of Novartis.

Indication

AFINITOR is a prescription medicine used to treat adults with a type of pancreatic cancer known as pancreatic neuroendocrine tumor (PNET) that has progressed and cannot be treated with surgery.

AFINITOR is not for use in people with carcinoid tumors that actively produce hormones.