DEVELOPING A TREATMENT PLAN

PATIENTS TALK ABOUT THEIR AFINITOR THERAPY

PATIENTS TALK ABOUT THEIR AFINITOR THERAPY
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AFINITOR PATIENT BROCHURE
 

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AFINITOR PATIENT BROCHURE
 

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Your Health Care Team

Getting to know your health care team

Making sure you have a knowledgeable health care team can make all the difference in the success of your treatment. Take the time to do some background research on the doctors, nurses, and other health care professionals who will be part of your team.

Your health care team can provide you with information about your PNET prognosis, treatment options, and patient-support programs. As your treatment journey continues, be sure to listen and communicate with your health care team in an honest and open way.

Some of the people on your health care team may include the following:

  • Oncologist: Oncologists are doctors who are specially trained to treat people with cancer. They are experts in the field of cancer and cancer therapies. In many cases, your health care team will be led by your oncologist. He or she will work with you to develop a plan of action and will remain with you throughout your journey.
  • Surgical Oncologist: This doctor has a medical degree in surgery with further training in the removal and treatment of cancerous tumors.
  • Oncology Nurse: Your oncology nurse works closely with your oncologist to implement your treatment plan and support your needs throughout treatment. Oncology nurses have gone through special training and certification to help treat people with cancer. A lot of your day-to-day contact with your oncologist's office will be through your oncology nurse. Your oncology nurse will be there to answer many of your questions and will also help you manage any side effects you may experience. It's likely that you will form a relationship with your oncology nurse as you travel along your treatment journey.
  • Oncology Clinic Staff: As they become the familiar and supportive faces that you encounter at most visits, your oncology clinic staff can be a valuable resource for information about advanced PNET and your treatment. They can also refer you to online support organizations. They will become familiar and supportive faces you will see at most visits.
  • Oncology Social Worker: An oncology social worker can help counsel patients and their families on coordinating cancer care, learning coping skills, and adjusting to changes in lifestyle. They may also help connect people to cancer support groups in the community and aid with any financial concerns.
  • Case Manager: A case manager (or care manager) is a person with training and experience in helping coordinate the care of people with cancer. Case managers are usually assigned to you through your health plan and can assist with any insurance issues and help determine your coverage.

Build strong relationships with your health care team

Your doctors and nurses are here to help you with your advanced PNET. It is best to speak openly with them about how you feel and your treatment. Here are a few suggestions to help you get the most out of your treatment with AFINITOR® (everolimus) Tablets:

  • Track your symptoms. Keep a record of how you are feeling and share it with your health care team at each visit
  • Take your medication as prescribed. Follow all the instructions from your doctor, nurse, or pharmacist
  • Communicate openly. Get comfortable letting your team know about all of your symptoms

Important Safety Information

AFINITOR can cause serious side effects that can even lead to death. If patients experience these side effects, they may need to stop taking AFINITOR for a while or use a lower dose. Patients should follow their health care provider’s instructions.

Please see additional Important Safety Information at the bottom of this page.

Please see full Prescribing Information for AFINITOR, including Patient Information.

 

Important Safety Information

AFINITOR® (everolimus) Tablets can cause serious side effects, including lung or breathing problems, infections, and kidney failure, which can lead to death. Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. AFINITOR can cause incisions to heal slowly or not heal well. Mouth ulcers and mouth sores are common side effects, occurring in up to 86% of patients taking AFINITOR. AFINITOR can affect blood cell counts, kidney and liver function, and blood sugar and cholesterol levels. Regular blood tests should be performed before starting AFINITOR and as needed during treatment to check blood cell count, kidney and liver function, and blood sugar and cholesterol levels.

Please see additional

Important Safety Information.

 
 

Important Safety Information

Patients should not take AFINITOR if they are allergic to AFINITOR or to any of its ingredients. Patients should tell their health care provider before taking AFINITOR if they are allergic to sirolimus (Rapamune®) or temsirolimus (Torisel®).

AFINITOR can cause serious side effects that can even lead to death. If patients experience these side effects, they may need to stop taking AFINITOR for a while or use a lower dose. Patients should follow their health care provider's instructions. Serious side effects include:

Lung or Breathing Problems: In some patients, lung or breathing problems may be severe and can even lead to death. Patients should tell their health care provider right away if they have any of these symptoms: new or worsening cough, shortness of breath, chest pain, difficulty breathing, or wheezing.

Infections: AFINITOR may make patients more likely to develop an infection, such as pneumonia, or a bacterial, fungal, or viral infection. Viral infections may include reactivation of hepatitis B in people who have had hepatitis B in the past. In some people these infections may be severe and can even lead to death. Patients may need to be treated as soon as possible. Patients should tell their health care provider right away if they have a temperature of 100.5˚F or above, have chills, or do not feel well. Symptoms of hepatitis B or infection may include the following: fever, chills, skin rash, joint pain and inflammation, tiredness, loss of appetite, nausea, pale stools or dark urine, yellowing of the skin, or pain in the upper right side of the stomach.

Angioedema: Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. Talk with your health care provider before taking AFINITOR if you are not sure if you take an ACE inhibitor medicine. Get medical help right away if you have trouble breathing or develop swelling of your tongue, mouth, or throat during treatment with AFINITOR.

Kidney Failure: Patients taking AFINITOR may develop kidney failure. In some people this may be severe and can even lead to death. Patients should have tests to check their kidney function before and during their treatment with AFINITOR.

Delayed Wound Healing: AFINITOR can cause incisions to heal slowly or not heal well. Call your health care provider right away if your incision is red, warm, or painful; if you have blood, fluid, or pus in your incision; if your incision opens up; or if your incision swells.

Before taking AFINITOR, tell your health care provider about all your medical conditions, including if you:

Tell your health care provider about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Using AFINITOR with certain other medicines can cause serious side effects. Keep a list of medicines you take and show it to your health care provider when you get a new medicine. Especially tell your health care provider if you take St John’s wort (Hypericum perforatum), medicines that weaken your immune system (your body’s ability to fight infections and other problems), or medicines for:

  • Fungal infections
  • Bacterial infections
  • Tuberculosis
  • Seizures
  • HIV-AIDS
  • Heart conditions or high blood pressure
 

If you are taking any medicines for the conditions listed above, your health care provider might need to prescribe a different medicine or your dose of AFINITOR may need to be changed. Tell your health care provider before you start taking any new medicine.

Common Side Effects: Common side effects include mouth ulcers. AFINITOR can cause mouth ulcers and sores. Tell your health care provider if you have pain, discomfort, or open sores in your mouth. Your health care provider may tell you to use a special mouthwash or gel that does not contain alcohol, hydrogen peroxide, iodine, or thyme.

Other common side effects include:

  • Rash, dry skin, and itching
  • Diarrhea
  • Infections
  • Feeling weak or tired
  • Swelling of arms, hands, feet, ankles, face, or other parts of the body
  • Stomach pain
  • Nausea
  • Fever
  • Loss of appetite, weight loss
  • Headache
  • Vomiting
  • Cough, shortness of breath
  • Nose bleed
  • Nail disorders
 

Tell your health care provider if you have any side effect that bothers you or does not go away.

These are not all the possible side effects of AFINITOR. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information for AFINITOR, including Patient Information.

The brands listed are the trademarks or register marks of their respective owners and are not trademarks or register marks of Novartis.

Indication

AFINITOR is a prescription medicine used to treat adults with a type of pancreatic cancer known as pancreatic neuroendocrine tumor (PNET) that has progressed and cannot be treated with surgery.

AFINITOR is not for use in people with carcinoid tumors that actively produce hormones.