ABOUT AFINITOR FOR ADVANCED PNET

PATIENTS TALK ABOUT THEIR AFINITOR THERAPY

PATIENTS TALK ABOUT THEIR AFINITOR THERAPY
CLICK HERE TO WATCH
 

HELPFUL RESOURCE FOR YOUR TREATMENT JOURNEY

AFINITOR PATIENT BROCHURE
 

LEARN MORE IN THE AFINITOR PATIENT BROCHURE

AFINITOR PATIENT BROCHURE
 

GET THE AFINITOR CO-PAY CARD

IMAGE: AFINITOR CO-PAY CARD
 

*Limitations apply. This offer is not valid under Medicare, Medicaid, or any other federal or state program. Novartis reserves the right to rescind, revoke, or amend this program without notice

 

Taking AFINITOR

Before starting treatment with AFINITOR

Before you start treatment with AFINITOR® (everolimus) Tablets, it is important to tell your doctor about all prescription and nonprescription medicines, vitamins, and herbal supplements you are taking. This is important because some of these may affect how AFINITOR works, or AFINITOR may affect how they work. Using AFINITOR with other medicines can cause serious side effects.

Keep a list of medicines you take and show it to your health care provider when you get a new medicine.

Especially tell your doctor if you take St John’s wort (Hypericum perforatum), medicines that weaken your immune system (your body’s ability to fight infections and other problems), or medicines for:

  • Fungal infections
  • Bacterial infections
  • Tuberculosis
  • Seizures
  • HIV-AIDS
  • Heart conditions or high blood pressure

Ask your health care provider or pharmacist if you are not sure if your medicine is one of those taken for the conditions listed above. If you are taking any medicines for the conditions listed above, your health care provider might need to prescribe a different medicine or your dose of AFINITOR may need to be changed. You should also tell your health care provider before you start taking any new medicine.

Important Safety Information

Lung or Breathing Problems: In some patients, lung or breathing problems may be severe and can even lead to death. Patients should tell their health care provider right away if they have any of these symptoms: new or worsening cough, shortness of breath, chest pain, difficulty breathing, or wheezing.

Please see additional Important Safety Information at the bottom of this page.

Please see full Prescribing Information for AFINITOR, including Patient Information.

Other things to tell your doctor before taking AFINITOR

Talk to your health care provider before taking this medicine if you are allergic to:

  • Sirolimus (Rapamune®)
  • Temsirolimus (Torisel®)

Before taking AFINITOR, tell your health care provider about all of your medical conditions, including if you:

  • Have or have had kidney problems
  • Have or have had liver problems
  • Have diabetes or high blood sugar
  • Have high blood cholesterol levels
  • Have any infections
  • Previously had hepatitis B
  • Are scheduled to receive any vaccinations. You should not receive a live vaccine or be around people who have recently received a live vaccine during your treatment with AFINITOR. If you are not sure about the type of vaccine, ask your health care provider
  • Have other medical conditions
  • Are pregnant or could become pregnant. AFINITOR can cause harm to your unborn baby. If you are able to become pregnant, you should use effective birth control while using AFINITOR and for 8 weeks after your last dose. Talk to your health care provider about birth control options while taking AFINITOR.
  • Are breastfeeding or plan to breastfeed. Do not breastfeed during treatment and for 2 weeks after your last dose.

Possible drug interactions with AFINITOR

Some kinds of medicines may lower or raise the amount of AFINITOR in your blood. Your doctor may need to change the dose of these medicines, the dose of AFINITOR, or prescribe a totally different medicine. Be sure to tell your doctor if you are taking any other medicines including (prescription or nonprescription) medicines, vitamins, or herbal supplements.

The following medicines may lower or raise the amount of AFINITOR in your blood. This list does not include all the medicines that may affect the amount of AFINITOR in your blood. Check with your doctor for additional medications that might interact with AFINITOR.

Medicines for seizures:

  • Carbamazepine
  • Phenobarbital
  • Phenytoin

Medicines for tuberculosis:

  • Rifabutin
  • Rifampin
  • Rifapentine

Medicines for infections:

  • Clarithromycin
  • Erythromycin
  • Telithromycin

Medicines for nausea and vomiting:

  • Aprepitant

Medicines for fungal infections:

  • Fluconazole
  • Itraconazole
  • Ketoconazole
  • Voriconazole
  • Nefazodone

Medicines for HIV/AIDS:

  • Amprenavir
  • Atazanavir
  • Fosamprenavir
  • Indinavir
  • Nelfinavir
  • Ritonavir
  • Saquinavir

Medicines for heart conditions and high blood pressure:

  • Diltiazem
  • Verapamil

The names of the medicines in this list are generic and may be different from the branded names of your medicines. Ask your health care provider or pharmacist if you are not sure if any of your medicines is one of those listed above.

Foods to avoid:

You should not drink grapefruit juice or eat grapefruit during your treatment with AFINITOR. It may make the amount of AFINITOR in your blood increase to a harmful level.

Important Safety Information

Angioedema: Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. Talk with your health care provider before taking AFINITOR if you are not sure if you take an ACE inhibitor medicine. Get medical help right away if you have trouble breathing or develop swelling of your tongue, mouth, or throat during treatment with AFINITOR.

Please see additional Important Safety Information at the bottom of this page.

Please see full Prescribing Information for AFINITOR, including Patient Information.

 

Important Safety Information

AFINITOR® (everolimus) Tablets can cause serious side effects, including lung or breathing problems, infections, and kidney failure, which can lead to death. Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. AFINITOR can cause incisions to heal slowly or not heal well. Mouth ulcers and mouth sores are common side effects, occurring in up to 86% of patients taking AFINITOR. AFINITOR can affect blood cell counts, kidney and liver function, and blood sugar and cholesterol levels. Regular blood tests should be performed before starting AFINITOR and as needed during treatment to check blood cell count, kidney and liver function, and blood sugar and cholesterol levels.

Please see additional

Important Safety Information.

 
 

Important Safety Information

Patients should not take AFINITOR if they are allergic to AFINITOR or to any of its ingredients. Patients should tell their health care provider before taking AFINITOR if they are allergic to sirolimus (Rapamune®) or temsirolimus (Torisel®).

AFINITOR can cause serious side effects that can even lead to death. If patients experience these side effects, they may need to stop taking AFINITOR for a while or use a lower dose. Patients should follow their health care provider's instructions. Serious side effects include:

Lung or Breathing Problems: In some patients, lung or breathing problems may be severe and can even lead to death. Patients should tell their health care provider right away if they have any of these symptoms: new or worsening cough, shortness of breath, chest pain, difficulty breathing, or wheezing.

Infections: AFINITOR may make patients more likely to develop an infection, such as pneumonia, or a bacterial, fungal, or viral infection. Viral infections may include reactivation of hepatitis B in people who have had hepatitis B in the past. In some people these infections may be severe and can even lead to death. Patients may need to be treated as soon as possible. Patients should tell their health care provider right away if they have a temperature of 100.5˚F or above, have chills, or do not feel well. Symptoms of hepatitis B or infection may include the following: fever, chills, skin rash, joint pain and inflammation, tiredness, loss of appetite, nausea, pale stools or dark urine, yellowing of the skin, or pain in the upper right side of the stomach.

Angioedema: Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. Talk with your health care provider before taking AFINITOR if you are not sure if you take an ACE inhibitor medicine. Get medical help right away if you have trouble breathing or develop swelling of your tongue, mouth, or throat during treatment with AFINITOR.

Kidney Failure: Patients taking AFINITOR may develop kidney failure. In some people this may be severe and can even lead to death. Patients should have tests to check their kidney function before and during their treatment with AFINITOR.

Delayed Wound Healing: AFINITOR can cause incisions to heal slowly or not heal well. Call your health care provider right away if your incision is red, warm, or painful; if you have blood, fluid, or pus in your incision; if your incision opens up; or if your incision swells.

Before taking AFINITOR, tell your health care provider about all your medical conditions, including if you:

Tell your health care provider about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Using AFINITOR with certain other medicines can cause serious side effects. Keep a list of medicines you take and show it to your health care provider when you get a new medicine. Especially tell your health care provider if you take St John’s wort (Hypericum perforatum), medicines that weaken your immune system (your body’s ability to fight infections and other problems), or medicines for:

  • Fungal infections
  • Bacterial infections
  • Tuberculosis
  • Seizures
  • HIV-AIDS
  • Heart conditions or high blood pressure
 

If you are taking any medicines for the conditions listed above, your health care provider might need to prescribe a different medicine or your dose of AFINITOR may need to be changed. Tell your health care provider before you start taking any new medicine.

Common Side Effects: Common side effects include mouth ulcers. AFINITOR can cause mouth ulcers and sores. Tell your health care provider if you have pain, discomfort, or open sores in your mouth. Your health care provider may tell you to use a special mouthwash or gel that does not contain alcohol, hydrogen peroxide, iodine, or thyme.

Other common side effects include:

  • Rash, dry skin, and itching
  • Diarrhea
  • Infections
  • Feeling weak or tired
  • Swelling of arms, hands, feet, ankles, face, or other parts of the body
  • Stomach pain
  • Nausea
  • Fever
  • Loss of appetite, weight loss
  • Headache
  • Vomiting
  • Cough, shortness of breath
  • Nose bleed
  • Nail disorders
 

Other side effects that may occur with AFINITOR:

 

Tell your health care provider if you have any side effect that bothers you or does not go away.

These are not all the possible side effects of AFINITOR. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information for AFINITOR, including Patient Information.

The brands listed are the trademarks or register marks of their respective owners and are not trademarks or register marks of Novartis.

Indication

AFINITOR is a prescription medicine used to treat adults with a type of pancreatic cancer known as pancreatic neuroendocrine tumor (PNET) that has progressed and cannot be treated with surgery.

AFINITOR is not for use in people with carcinoid tumors that actively produce hormones.