About Afinitor for Advanced Renal Cell Carcinoma (RCC)
Causes and Risk Factors of Advanced Renal Cell Carcinoma (aRCC)
What are the causes of kidney cancer?
All of the cells in your body contain genes. Genes contain the instructions that tell cells what to do. Cells become cancerous when something changes, or mutates, those instructions. This mutation causes the cells to keep dividing, making more and more cancer cells.
If you have advanced kidney cancer, cancer cells from your kidneys have spread through your body and formed tumors in other places.
Unlike some other diseases, there is no one cause of advanced kidney cancer. Researchers think that genetic factors increase your risk of getting kidney cancer. They also think that nongenetic factors, such as smoking and obesity, may be involved. Scientists have studied advanced kidney cancer for years, but do not completely understand how it develops. Continuing research may eventually provide answers.
What are the risk factors for kidney disease?
Knowing some of the risks of kidney cancer is an important way to be proactive about your health.
The most common kidney cancers are renal cell carcinomas. While there is no single known cause of kidney cancer, the risk factors include:
- Age: As a person gets older, the risk of renal cell carcinoma increases. This disease occurs mostly in people older than 55 years old
- Gender: Men are more likely than women to develop renal cell carcinoma
- Smoking: People who smoke have a higher risk. The good news is that quitting smoking can reduce your risk
- Obesity: People who are overweight have an increased risk of renal cell carcinoma
- High blood pressure: Although the reason is unclear, high blood pressure seems to increase the risk of renal cell carcinoma
- Chemical exposure in the workplace: People who work with certain chemicals (such as asbestos, cadmium, and trichloroethylene) may have an increased risk of renal cell carcinoma
- Treatment for kidney failure: People with chronic kidney failure who have been treated with long-term dialysis, and people who have had a kidney transplant and take immunosuppressant medication have a higher risk of developing renal cell carcinoma
- Genetic factors: Certain inherited disorders make a person more likely to develop one or more types of renal cell carcinomas
It is estimated that over 64,000 people in the United States will be diagnosed with cancer of the kidney in 2012. Currently, there are more than 200,000 kidney cancer survivors living in the United States.
AFINITOR is used to treat people with a form of advanced kidney cancer (renal cell carcinoma or RCC) when certain other medicines (ie, Sutent® [sunitinib] or Nexavar® [sorafenib]) have not worked.
ADVANCED RENAL CELL CARCINOMA (aRCC)
AFINITOR® (everolimus) Tablets is a prescription medicine used to treat adults with advanced kidney cancer (renal cell carcinoma or RCC) when certain other medicines (ie, Sutent® [sunitinib] or Nexavar® [sorafenib]) have not worked.
Important Safety Information
AFINITOR can cause serious side effects, including lung or breathing problems, infections, and kidney failure, which can lead to death. Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. AFINITOR can cause incisions to heal slowly or not heal well. Mouth ulcers and mouth sores are common side effects, occurring in up to 78% of patients taking AFINITOR. AFINITOR can affect blood cell counts, kidney and liver function, and blood sugar and cholesterol levels. Regular blood tests should be performed before starting AFINITOR and as needed during treatment to check blood cell count, kidney and liver function, and blood sugar and cholesterol levels.
Please see additional
Please see full Prescribing Information for AFINITOR, including Patient Information.