About Afinitor for Advanced Renal Cell Carcinoma (RCC)
Surgical Options for Advanced Kidney Cancer
Choosing the right surgery for you
The first step in treating kidney cancer is usually surgery. Surgery to remove a kidney is called nephrectomy. There are several types of nephrectomy. You and your surgeon will decide which type is right for you.
- Radical nephrectomy removes the whole kidney and some small organs and tissue near the kidney. This is the most common surgery for advanced kidney cancer
- Partial nephrectomy removes only the tumor and nearby kidney tissue. The rest of the kidney is left in place. This type of surgery is used when the tumor is small (i.e., less than four centimeters). It is also used if the patient only has one kidney or if there is cancer in both kidneys
What to expect after your surgery
After surgery you may feel weak and tired for several weeks, but it is important to remember that people do not really need two kidneys. One healthy kidney will work harder to make up for the kidney that was removed. You can even live with only part of one kidney if some of it is removed by surgery.
An alternative step to surgery
Another procedure you and your doctor may talk about as you create your treatment plan is arterial embolization. This procedure involves blocking the blood supply to a tumor. Blocking the blood supply makes the tumor shrink.
Arterial embolization has many uses:
- It can take the place of surgery as some people cannot have surgery, for example, because a kidney is already damaged
- It can be used before surgery to shrink the tumor. This may make surgery easier to perform
- It may also be used to help relieve the symptoms of advanced kidney cancer, such as pain or blood in the urine
What happens during arterial embolization?
If arterial embolization is a step you and your doctor decide to take, you will need to go to the hospital. Your doctor will insert a narrow tube into your leg. The tube will go up to the main blood vessel of your kidney. Your doctor will inject a substance into the blood vessel that will block blood from flowing into the kidney. Blocking blood keeps the tumor from getting oxygen and other nutrients it needs to grow.
ADVANCED RENAL CELL CARCINOMA (aRCC)
AFINITOR® (everolimus) Tablets is a prescription medicine used to treat adults with advanced kidney cancer (renal cell carcinoma or RCC) when certain other medicines (ie, Sutent® [sunitinib] or Nexavar® [sorafenib]) have not worked.
Important Safety Information
AFINITOR can cause serious side effects, including lung or breathing problems, infections, and kidney failure, which can lead to death. Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. AFINITOR can cause incisions to heal slowly or not heal well. Mouth ulcers and mouth sores are common side effects, occurring in up to 78% of patients taking AFINITOR. AFINITOR can affect blood cell counts, kidney and liver function, and blood sugar and cholesterol levels. Regular blood tests should be performed before starting AFINITOR and as needed during treatment to check blood cell count, kidney and liver function, and blood sugar and cholesterol levels.
Please see additional
Please see full Prescribing Information for AFINITOR, including Patient Information.