Here are some helpful definitions of medical terms you may come across in this site.
Cerebrospinal fluid: A fluid that normally flows through the cavities of the brain.
Foramen of Monro: The small opening on both the right and left sides of the brain that connects the third ventricle with the lateral ventricles (the spaces in the brain through which cerebrospinal fluid flows). The foramen of Monro is often the site of growth for SEGAs.
Hydrocephalus: The buildup of fluid in the cavities (ventricles) deep within the brain. The excess fluid increases the size of the ventricles and puts pressure on the brain.
Live vaccine: A vaccine that is prepared from live organisms (such as bacteria and viruses) that have been weakened. Live vaccines may include measles, mumps, rubella, chicken pox, and the nasal flu vaccine.
Mouth ulcers: Sores or open lesions in the mouth.
mTOR: Mammalian target of rapamycin is an important protein that is present in both normal cells and tumor cells. It controls tumor cell growth as well as the supply of blood and nutrients to the tumor.
SEGA: Subependymal giant cell astrocytoma; noncancerous brain tumors that can occur in up to 20% of patients with TSC.
SEN: Subependymal nodule; small noncancerous brain tumors that occur in 95% of patients with TSC.
TSC1 and TSC2 genes: Genes that form proteins that help control an important regulator of cell growth call mTOR. In SEGA patients, either TSC1 or TSC2 does not work properly, which may cause tumors to grow.
Tuberous sclerosis complex (TSC): Tuberous sclerosis complex is a genetic disorder that may cause benign tumors to form in vital organs and can affect many different parts of the body, including the brain.
Important Safety Information
AFINITOR or AFINITOR DISPERZ™ can cause serious side effects which can even lead to death. If patients experience these side effects, they may need to stop taking AFINITOR or AFINITOR DISPERZ™ for a while or use a lower dose. Patients should follow their health care provider's instructions.
SEGA With TSC
AFINITOR® (everolimus) Tablets and AFINITOR DISPERZTM (everolimus tablets for oral suspension) are prescription medicines used to treat adults and children with a genetic condition called tuberous sclerosis complex (TSC) who have a brain tumor called subependymal giant cell astrocytoma (SEGA) when the tumor cannot be removed completely by surgery.
Important Safety Information
AFINITOR can cause serious side effects, including lung or breathing problems, infections, and kidney failure, which can lead to death. Patients who take an angiotensin-converting enzyme (ACE) inhibitor medicine during treatment with AFINITOR are at a possible increased risk for a type of allergic reaction called angioedema. AFINITOR can cause incisions to heal slowly or not heal well. Mouth ulcers and mouth sores are common side effects, occurring in up to 78% of patients taking AFINITOR. AFINITOR can affect blood cell counts, kidney and liver function, and blood sugar and cholesterol levels. Regular blood tests should be performed before starting AFINITOR and as needed during treatment to check blood cell count, kidney and liver function, blood sugar and cholesterol levels, and how much AFINITOR is in the blood.
Please see additional Important Safety Information.
Please see full Prescribing Information for AFINITOR, including Patient Information.